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Cancer research  

The following publications of Albert Rübben have been partly financed by government institutions as well as by personal contributions of Albert Rübben.

The system science concept behind these publications is that carcinogenesis and tumor progression follow the laws of evolution with mutation acquisition and selection as major driving forces. The work focuses on molecular techniques which allow quantifying genetic heterogeneity within small clusters of cancer cells.


Rübben A, Babilas P, Baron JM, Hofheinz A, Neis M, Sels F, Sporkert M. Analysis of tumor cell evolution in a melanoma: evidence of mutational and selective pressure for loss of p16ink4 and for microsatellite instability. J Invest Dermatol. 2000 Jan;114(1):14-20.  

Rübben A, Bogdan I, Grussendorf-Conen EI, Burg G, Böni R. Loss of heterozygosity and microsatellite instability in acquired melanocytic nevi: towards a molecular definition of the dysplastic nevus. Recent Results Cancer Res. 2002;160:100-10.  

Rübben A, Kempf W, Kadin ME, Zimmermann DR, Burg G. Multilineage progression of genetically unstable tumor subclones in cutaneous T-cell lymphoma. Exp Dermatol. 2004 Aug;13(8):472-83  

Rübben A, Bausch B, Nikkels A. Somatic deletion of the NF1 gene in a neurofibromatosis type 1-associated malignant melanoma demonstrated by digital PCR. Mol Cancer. 2006 Sep 10;5:36.

Rübben A, Nordhoff O. A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution Biology Open 2012 BIO20122543; Advance Online Publication November 12, 2012, doi:10.1242/bio.20122543